Journal of science and technology Beijing, July 25 (xinhua Tang Xianwu correspondent Shen Jifei) the reporter learns from 25 military academy of medical sciences, the school field stem cells and regenerative medicine, key laboratory of institute of blood transfusion and army xue-tao pei team after over 10 years, established the "artificial blood" preparation technology, and through stem cell technology, the successful preparation of the "artificial red blood cells. The "artificial red blood cells and normal red blood cells, hemoglobin content, ability to carry oxygen and osmotic fragility of the indicators, is the source of stem cells, in vitro preparation closest to the clinical application of biological science and technology achievements, amplification rate can reach more than 100000 times, make preparation" artificial blood "stem cell research and development of our country has entered the international first-class.
Expert introduction, directly by the stem cells in vitro "production" of red blood cells, the cells will have the same physiological function normal red blood cells, at the same time also can guarantee according to the requirements of "production" generic type (O) or rare genetic background of red blood cells, blood type in vitro preparation program also can utmost ground to avoid the occurrence of infectious diseases. Although the United States, France, Britain and other countries in the research and development on preparation of "artificial blood stem cells obtained some progress, but with larger difference exist in clinical application. The key is to achieve clinical application has not yet been breakthrough level of scale expansion.
Xue-tao pei team established procedural efficient amplification and blood stem cells induced directional differentiation and key technologies include "stem cells and progenitor cells, terminal" three key links, improve the efficiency of the stem cell directional differentiation and amplification, new breakthrough in link of large-scale preparation of red blood cells. The team induced preparation of red blood cells transplanted into mice, 4 days can be detected living cells, and cells is presented typical double concave structure, artificial red blood cells and detect the specific antigen, showed that the preparation of red blood cells with normal stem cell technology using human red blood cell structure and function. Next, the team is committed to large-scale preparation of red blood cells, plasma composite with specific functions, form a complete physiological function of new type of "artificial blood".